Study of Losartan’s Effects on Different Biochemical Parameters in Essential Hypertensive Patients
The renin-angiotensin system (RAS) regulates blood pressure the most effectively, and angiotensin II is the main mediator in this system. Angiotensin II binds to AT1 receptors and causes a multitude of potentially detrimental effects, including blood pressure elevation, atherosclerosis progression, and myocardial and vascular hypertrophy. Losartan was the first...
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Novel Simultaneous Separation and Quantitative Determination of Four Sartans in Presence of Hydrochlorothiazide by Isocratic RP-HPLC
A simple, reliable, sensitive, reproducible and novel isocratic RP-HPLC method was developed and validated for the separation and quantitative estimation of four angiotensin II-receptor antagonists namely Telmisartan (TELM), Losartan (LOSA), Olmesartan (OLME) and Valsartan (VALS) that are utilized in treating hypertension alone or along with some other drugs like...
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