Effect of Orally Ebselen (SPI-1005) towards Glutathione and Malondialdehyde Blood Level and Otoacoustic Emissions Result in Soldiers with Acoustic Trauma Risk
Excessive noise exposure can cause acoustic trauma to the inner ear structure (cochlea) by creating mechanical and metabolic (oxidative) stress (TA). Oxidative stress, which is induced by an increase in free radical ROS/RNS in the organs of Corti, causes apoptosis and necrosis of cochlear hair cells. Increased malondialdehyde (MDA),...
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