Tag: Glioblastoma

A Case Report on Delayed Diagnosis of Glioblastoma

The clinical and radiological indications of a concomitant tumour may be hidden by the rupture of a cerebral aneurysm. The goal of this study is to raise awareness about the dangers of delayed diagnosis by recounting the case of a patient who had a subarachnoid haemorrhage that hid the...
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Study on Proteomic Profiling of High-grade Glioblastoma: Aspects of Biomarkers

Using two-dimensional electrophoresis (2DE), mass spectrometry (ESI LC-MS/MS), and immunodetection, researchers were able to identify and quantify different proteoforms (protein species) present in a cell line derived from a high-grade glioblastoma cell line. It was possible to obtain a 2DE protein map with a large data set of 937...
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Assessing the Impact of MGMT Promoter Methylation as a Prognostic Marker in Patients with Glioma- A Single-Center Observational Study

Background: Via promoter hypermethylation in gliomas, the MGMT gene is epigenetically silenced and this alteration has emerged as a important therapeutic response predictor. The current study was aimed at correlating O6-methylguanine-DNAmethyltransferase (MGMT promoter gene) methylation status with response to alkylating agent-based therapy in high-grade gliomas Methods: For MGMT promoter...
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