Tag: Crohn’s disease

Why Biologics are Ultimaely a Failed Therapy for Crohns Disease

Since its introduction in 2003, a biologic has prevailed as the drug of choice in the treatment of Crohn’s disease. Its dominance for the past two decades is poorly supported by its limited therapeutic efficacy. In 2001, Infectious Diseases Incorporated entered a strategic alliance with the University of Florida...
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Dietary Therapy of Crohn’s Disease: The IDI Synthesis

In rare instances of Crohn’s disease, dietary modifications have produced what biologics and steroids haven’t yet shown to be possible: long-lasting remissions or cures. The quantitative availability of vitamins, minerals, and certain amino acids that are necessary for the immune system to operate at its best are compromised in...
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Crohn’s Disease: A Curable Disease Held Hostage?

 The present focus of Crohn’s disease treatment has been sclerosed for a long time. In 40% of cases, biologics cause brief remissions. They have yet to achieve long-term remissions. The FDA’s insistence on clinical validation through comparative, placebo-controlled, double-blinded trials has created a barrier to the acceptance of alternative...
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TNF-α Inhibitor Treatment for Crohn’s Disease: Comparative Review of Post Therapy Malignancy between Infliximab and Adalimumab

The association between chronic inflammatory disease and cancer has been well established through years of research. In corollary, progressive resistance to chimeric monoclonal antibodies has been reported in literature. The purpose of this investigation was to establish the overall trend of the chimeric monoclonal antibody (Infliximab) failure compared with...
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