Tag: ATRA

Study on Potentiation of ATRA Activity in HL-60 Cells by Targeting Methylation Enzymes

All Trans Retinoic Acid (ATRA) is a clinically established Differentiation Inducer (DI) for Acute Promyelocytic Leukemia (APL). Its efficacy in treating other kinds of Acute Myelocytic Leukemia (AML) is limited. ATRA targets the PML-RARA (promyelocytic leukemia/retinoic acid receptor-alpha)/DNA methyltransferase (DNMT)/Histone Deacetylase (HDAC) complex in APL, causing gene silencing to...
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Study on Potentiation of ATRA Activity in HL-60 Cells by Targeting Methylation Enzymes

All Trans Retinoic Acid (ATRA) is a clinically established Differentiation Inducer (DI) for Acute Promyelocytic Leukemia (APL). Its efficacy in treating other kinds of Acute Myelocytic Leukemia (AML) is limited. ATRA targets the PML-RARA (promyelocytic leukemia/retinoic acid receptor-alpha)/DNA methyltransferase (DNMT)/Histone Deacetylase (HDAC) complex in APL, causing gene silencing to...
Read More