Development and Validation of a Stability Indicating Related Substances of Atenolol and Nitrendipine by RP-HPLC
The present study analyzed a validated security-indicating RP-HPLC plan for Atenolol and Nitrendipine was developed by separating allure related impurities. Atenolol is a discriminating beta 1 blocker that maybe used alone or together with hydrochlorothiazide or with chlorthalidone for the situation of hypertension and prevention from a heart failure.By...
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Formulation and In –Vitro Evaluation of Bilayer Tablet of Atenolol for Biphasic Drug Release: Experimental Investigation
The purpose of this study was to create a bilayer atenolol tablet for biphasic drug release in order to increase bioavailability and absorption in the lower GI tract. The super disintegrants croscarmellose sodium and sodium starch glycolate were utilised in the formulation of instant release crosspovidone, which was then...
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Design of Bitterless Atenolol Prodrugs for the Use in Aqueous Formulations for Pediatrics and Geriatrics
A number of atenolol prodrugs were created using DFT, MP2, and hybrid GGA: MPW1k calculations for an acid-catalyzed hydrolysis of nine Kirby’s N-alkylmaleamic acids. A linear association between the estimated and experimental rate values for the nine Kirby’s N-alkylmaleamic acids has provided a solid foundation for developing atenolol prodrugs...
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Experiments on Micellar Liquid Chromatographic Method for Simultaneous Determination of Atenolol and Aspirin in Bulk and Pharmaceutical Dosage Form
Micellar liquid chromatographic method has been developed for the simultaneous determination of Atenolol and Aspirin in a bulk drug and pharmaceutical formulation. Chromatographic separation achieved isocratically on ODS hypersil C18 column (5 μm, 250 mm × 4.6 mm) and micellar mobile phase of 0.07M sodium dodecyl sulfate (SDS) pH...
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