Impairment in Acetylcholinesterase Activity in Different Brain Parts of Female Mice, Mus musculus Following 17 α-Methyltestosterone (Anabolic- Androgenic Steroid)
Anabolic androgenic steroids (AAS) are synthetic versions of testosterone, the male sex hormone. In this study, we looked at the effects of one of the AAS chemicals, 17-methyltestosterone, on acethylcholinesterase (AChE) enzyme activity in the forebrain, hippocampus, midbrain, and hindbrain of mice. Adult female mice were randomly assigned to...
Read More
Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis and Their Anti-cholinesterase Activity
Vietnamese Huperzia squarrosa was isolated from a sequence of lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8pha-hydrophlemariurine B (5) and huperzinine (6). Among them, the latest natural source metabolite is lycosquarosine A (1). Dose-dependent AChE activity was completely inhibited by lycosquarosine A...
Read More