Tag: 2

In organic synthesis, multicomponent reactions (MCR) and cascade reactions are frequently used. Different substituted pyrazoles are accessed using these two synthetic methods. In the first section, we’re interested in learning how to make aminocyanopyrazoles using a multicomponent process. The current study outlines a useful protocol for multicomponent reactions (MCRs)...

This article has have as objective one: Present of two new algorithm for its application in the computers, with they we will can know all and of each of values 2𝑛 in polynomial time not only the individual values of (n) if no all values of an interval =...

The hunt for plant-based remedies for atopic dermatitis (AD), a recurrent dermatological disorder with a high prevalence in tropical areas, has always piqued interest. Oroxylum indicum Linn (Bignoniaceae) is a commonly used medicinal plant that has not yet been scientifically proven to be useful in the treatment of Alzheimer’s...

A Quinolino novel series[3,2-f] [1,2,4] The [3,4-b] Triazolo [1,3,4] The Thiadiazepine (7a-i) derivatives incorporated with 3-(5–i) (benzofuran-2-yl) -1-phenyl-1H-3-yl pyrazol) Moiety was synthesised by a 5-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)) one-point cyclo-condensation reaction. -4-amino-4H-1,2,4-triazole-3-thiol (4) in the presence of K2CO3 in DMF with 2-chloro-quinoline-3-carbaldehyde derivatives (6a-i). Characterization of 3-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-substituted quinolino [3,2-f] newly synthesised compounds...

Various biological activities have been found to demonstrate the compounds bearing sulfamoyl and acetamoyl groups. A series of O- and N-substituted derivatives, beginning with planetol (1), were synthesised in the present research work. Aq was used to treat the first N-methyl-4-hydroxyanilinium sulphate (1; planetol or metol) with various aryl...

Discovery of the biological potentialities of cytoxazone by Kakeya’s research group has leveraged the development of studies aimed at the synthesis of this compound. The stereoselective total synthesis of (+)-epi-cytoxazone was performed satisfactorily in 8 steps, in 17% overall yield, via a novel route from 2,3-O-(3-pentylidene)-(R)-glyceraldehyde. The bulky group...

As a continuation of our research on developing anticancer agents and based on the proven proprieties of thieno[2,3‐b]pyridines as anticancer, we have designed to synthesize novel thieno[2,3‐ b]pyridine derivatives that incorporate different biologically active heterocycles through various chemical reactions. All of the newly obtained compounds, compared with the standard...

The concept of sequential cytotoxicity indicates the successive release of two or more cytotoxic compounds causing grater toxicity to the neoplasm than normal cell. This hypothesis is evaluated by designing a series of compounds of 2, 6 diphenyl piperidine-4-one. Recently for the development of novel cytotoxic and anticancer agents,...

The alkylation reaction of 1H-1,2,4-triazole with (4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl-4-methylbenzenesulfonate in presence of K2CO3 as base and a catalytic amount of tetrabutylammonium bromide in N,N’-dimethylformamide, followed by an oxazoline ring-opening reaction in an acidic medium, and protection of amine function, leads normally to obtain two regioisomers of N-protected β-aminoalcohols with prevalence of...

The study of heterocyclic systems provides most fascinating field for exploration in view of variety of interesting and intricate reactions, which lead to synthesis of unusual systems having diversities in their skeletal pattern. In this context, various new heterocycles and derivatives are synthesized with increased biological activities and less...