Sulfonamides are a special class of chemicals with outstanding antibacterial properties. Sulpha medicines were the first efficient chemotherapeutic agents used to treat bacterial infections in humans, and they were shown to be resistant to Mycobacterium tuberculosis, Typhoid and Paratyphoid bacilli, and other germs. N-sulfonation of 2-substituted-pyrimido[1,2- a]benzimidazol-4(10H)-ones yielded a...