News Update on Iron Deficiency Anemia Research: May – 2019
Total dose iron dextran infusion versus oral iron for treating iron deficiency anemia in pregnant women: a randomized controlled trial
Study objective: to check safety, efficacy, and cost-effectiveness of total dose infusion (TDI) of low relative molecular mass (LMW) iron dextran for treatment of iron deficiency anemia (IDA) throughout physiological state compared to oral ferric fumarate.
Design: Prospective interventional irregular controlled trial (RCT). style classification. Canadian Task Force II3.
Setting: antepartum clinic and relation unit of a tertiary care referral facility and University Hospital.
Patients: a complete sixty six anemic pregnant girls (hemoglobin level between 7–10 g/dl).
Intervention: Administration of a LMW iron dextran as a TDI (group A) or Oral iron ferric fumarate 60 mg elemental iron thrice daily (group B) followed by remeasurement of haemoprotein once four weeks.
Measures and main results: the most outcome live was clinical and laboratory improvement of anemia once four weeks of beginning the medical care. each teams showed a major clinical improvement of anemia four weeks post-therapy. However, the primary improvement of symptoms was considerably quicker in type A. Complete blood count (CBC) further as all iron indices were improved in each teams once four weeks of medical care, however were considerably higher in type A than B. facet effects in B were in the main gi (GIT) whereas one case of gentle hypersensitivity to TDI and another one case of native reaction at the location of injection were reportable in type A.
Conclusions: it’s all over that despite being equally effective in up each clinical and laboratory proof of UN agency, TDI permits iron restoration with one dose quicker than oral iron medical care with an inexpensive safety profile. it’s an honest example of workplace one-stop medical care. still, noninvasive selfusage reception may be a clear advantage of the cheaper oral iron medical care that makes it the primary selection for treating UN agency within the second and third trimesters of physiological state in tolerable cases. [1]
Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative atrophic glossitis patients
Background/Purpose
Our previous study found that 177 of 1064 symptom inflammation (AG) patients have bodily fluid viscus membrane bone cell protein (GPCA) positivism solely (so-called GPCA+AG patients). This study assessed whether or not bodily fluid GPCA positivism or noble metal itself was a big issue inflicting medication deficiencies and hyperhomocysteinemia in GPCA+AG or GPCA-negative, iodinated protein protein (TGA)-negative, and thyroid granule protein (TMA)-negative noble metal (GPCA־TGA־TMA־AG) patients.
Methods
The mean blood haemoprotein (Hb), iron, B, folic acid, and homocysteine levels were measured and compared between any 2 of 3 teams of 177 GPCA+AG patients, 476 GPCA־TGA־TMA־AG patients, and 532 healthy management subjects.
Results
GPCA+AG patients had considerably lower mean blood hemoglobin and iron (for girls only) levels and a significantly higher mean bodily fluid homocysteine level than healthy management subjects. Moreover, GPCA+AG patients had considerably bigger frequencies of blood hemoglobin, iron, and B deficiencies and hyperhomocysteinemia than healthy management subjects. GPCA+AG patients have a lower mean bodily fluid B level and a considerably higher mean serum homocysteine level similarly as significantly bigger frequencies of B deficiency and hyperhomocysteinemia than GPCA־TGA־TMA־AG patients. Moreover, GPCA־TGA־TMA־AG patients did have considerably lower mean blood hemoglobin and iron levels and significantly bigger frequencies of blood Hb, iron, vitamin B12, and B complex deficiencies and hyperhomocysteinemia than healthy management subjects.
Conclusion
The GPCA may be a major factor inflicting B deficiency and hyperhomocyteinemia in GPCA+AG patients. noble metal itself will play a big role in inflicting anemia, medication deficiencies, and hyperhomocysteinemia in each GPCA+AG and GPCA־TGA־TMA־AG patients. [2]
Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis
Objective To perform a scientific review and meta-analysis of irregular controlled trials (RCTs) to assess the advantages of endovenous (IV) iron in physiological condition.
Study Design Systematic review was registered with PROSPERO and performed victimisation PRISMA pointers. PubMed, MEDLINE, net of Science, ClinicalTrials.gov, Cochrane Library, and Google Scholar were searched. Eleven RCTs, scrutiny IV to oral iron for treatment of iron-deficiency anemia in physiological condition, were enclosed. Meta-analyses were performed with Stata code (College Station, TX), utilizing random effects model and technique of DerSimonian and landholder. Outcomes were assessed by pooled odds ratios (OR) or pooled weighted mean distinction (WMD). Sensitivity analyses were performed for nonuniformity.
Results We found that pregnant girls receiving IV iron, compared with oral iron, had the subsequent benefits: (1) Achieved target haemoprotein a lot of typically, pooled OR two.66 (95% confidence interval [CI]: one.71–4.15), p [3]
Four years after implementation of a national micronutrient powder program in Kyrgyzstan, prevalence of iron deficiency and iron deficiency anemia is lower, but prevalence of vitamin A deficiency is higher
Background/Objectives:
In 2009, the Ministry of Health of Kirghiz launched a national baby and Young kid Nutrition (IYCN) program including point-of-use fortification of foods with matter powders (MNP) containing iron, vitamin A, and alternative micronutrients. Caretakers of youngsters aged 6–23 months got thirty sachets of MNP each a pair of months. matter surveys were conducted in 2009 and 2013. the target of the study was to match the prevalence of anemia and deficiencies of iron and axerophthol among kids aged 6–29 months before the MNP program (2009) with those once full implementation (2013).
Subjects/Methods:
Cross-sectional national surveys were conducted in 2009 (n = 666) and 2013 (n = 2150). Capillary blood samples were collected to live haemoprotein, iron (ferritin and soluble globulin receptor [sTfR]) and axerophthol (retinol binding macromolecule [RBP]) standing, and inflammation standing (C-reactive macromolecule [CRP] and α-1-acid conjugated protein [AGP]). Ferritin, sTfR, and RBP were adjusted for inflammation; haemoprotein was adjusted for altitude.
Results:
The prevalence of anemia was non-significantly lower in 2013 compared to 2009 (32.7% vs. 39.0%, p = 0.076). Prevalence of inflammation-adjusted iron deficiency (54.8% vs. 74.2%, p [4]
Iron Deficiency Anaemia Leading to Thrombocytopenia: A Case Report
Iron deficiency anaemia is usually related to symptom, but cases of blood disorder are rumored. continual cases of iron deficiency with blood disorder are even a lot of unusual; so, we have a tendency to gift a patient with continual blood disorder within the setting of intermittent iron deficiency anaemia. The mechanism of blood platelet count variation in response to iron remains poorly understood. There are multiple attainable explanations, as well as however not restricted to the diphasic response of blood platelets to glycoprotein and also the twin perform of iron in platelet production. This case highlights the importance of AN iron replacement trial for the people with documented iron deficiency and blood disorder. AN iron treatment trial might spare the patients with iron responsive blood disorder from a lot of invasive diagnostic modalities searching for primary bone marrow disorders.[5]
Reference
[1] Darwish, A.M., Khalifa, E.E., Rashad, E. and Farghally, E., 2019. Total dose iron dextran infusion versus oral iron for treating iron deficiency anemia in pregnant women: a randomized controlled trial. The Journal of Maternal-Fetal & Neonatal Medicine, 32(3), pp.398-403.(Web Link)
[2] Chiang, C.P., Chang, J.Y.F., Wang, Y.P., Wu, Y.H., Wu, Y.C. and Sun, A., 2019. Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative atrophic glossitis patients. Journal of the Formosan Medical Association.(Web Link)
[3] Govindappagari, S. and Burwick, R.M., 2019. Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis. American journal of perinatology, 36(04), pp.366-376.(Web Link)
[4] Four years after implementation of a national micronutrient powder program in Kyrgyzstan, prevalence of iron deficiency and iron deficiency anemia is lower, but prevalence of vitamin A deficiency is higher
Elizabeth A. Lundeen,Jennifer N. Lind,Kristie E. N. Clarke,Nancy J. Aburto,Cholpon Imanalieva,Tursun Mamyrbaeva,Asel Ismailova,Arnold Timmer,Ralph D. Whitehead Jr.,Larissa Praslova,Galina Samohleb,Muktar Minbaev,O. Yaw Addo &Mary K. Serdula
European Journal of Clinical Nutritionvolume 73, pages416–423 (2019)(Web Link)
[5] Torrejon, N., Calvo, A. and Pak, S. (2018) “Iron Deficiency Anaemia Leading to Thrombocytopenia: A Case Report”, International Journal of Research and Reports in Hematology, 1(2), pp. 1-4. Available at: http://www.journalijr2h.com/index.php/IJR2H/article/view/25656 (Accessed: 21May2019).(Web Link)