Low Dose Aspirin and Omega 3 Fatty Acids in the Pro Resolving Pathway of Cardiovascular Disorders

Newer mechanisms of action of Acetyl Salicylic acid have been discovered in proresolving pathway of various disorders. Omega 3 fatty acids are also involved in the synthesis of resolvins via an aspirin triggered pathway. The  present  review  aims  to  discuss  the  role  of  recently  discovered  aspirin triggered lipoxins, resolvins, protectins, maresins in understanding the pathophysiology of endothelial dysfunction  in  various  cardiovascular  disorders,  especially  hypertension.  The  concept  of  aspirin triggered lipoxins (15-epi-LXA4 and 15-epi-LX4)counteracting the action of LTB4.PGE2, and TXA2 is discussed. Aspirin triggered lipoxins also block the expression of IL-8 gene. Aspirin is the only known NSAID to induce NO in a dose dependent manner. In this chapter, we describe role of acetyl salicylic acid in the pro-resolution pathways that might prevent or reduce complications in patients with high blood pressure. Aspirin is a low cost intervention that can prevent the atherosclerosis of vessels by its anti-inflammatory, antiplatelet and proresolving abilities. Recent understanding of the pathophysiology of  hypertension  and  proresolving  pathways  can  help  to  understand  the  rational  use  of  aspirin  in prevention  and  reducing  the  complications  of  high  blood  pressure.  A  combination  of  aspirin  and omega 3 fatty acids has potential benefits. DHA metabolites have been found to have potent role in the resolution pathway of inflammation. Future endeavors would focus on the identification of subset of high-risk hypertensive patients who will benefit most from aspirin, omega 3 fatty acids and DHA. Different  dosage  and  time  of  initiation  in  various  high-risk  groups  needs  to  be  identified.  Further research is also required to identify the correct time and the oral doses that will help in minimizing the long-term risk of future cardiovascular diseases.

Read full article: http://bp.bookpi.org/index.php/bpi/catalog/view/42/179/324-1


Leave a Reply

Your email address will not be published. Required fields are marked *