Granulomatous Lobular Mastitis: A Clinicopathological Study

Granulomatous Lobular Mastitis is a rather uncommon illness. This condition resembles cancer and tuberculosis. This syndrome is characterised by granulomatous inflammation with multinucleated large cells and epithelioid histiocytes. The inflammation is concentrated in the lobules. The purpose of this study is to look at the clinical and pathological features of eight cases of granulomatous lobular mastitis, as well as the literature.

The research is based on a prospective observational study. There were a total of eight patients examined. The investigations are now concluded. The patient was given Erythromycin 250 mg qid for seven days, Tinidazole 500 mg bid for two months, and steroids for seven days. After the tumours were removed, the sinuses were excised, and the abscesses were drained, oral steroids were given. There was a six-month follow-up.

The patients, who ranged in age from 18 to 36, were usually multiparous and nursing. In three cases, the lesion was found to be malignant, while in five others, it was found to be benign. Oral contraceptive tablets were used by the majority of the patients. In three cases, suppuration was observed, while sinuses were discovered in two others. On histological examination, a granulomatous inflammation centred on the lobules was found.

Conclusion: The diagnosis of granulomatous lobular mastitis should be established very carefully to avoid misunderstandings with malignancy, tuberculosis, fungal infection, sarcoidosis, mammary duct ectasia, cystic abnormalities in the breast with over palpation, and puerperal mastitis with over palpation. Despite its rarity, pathologists and surgeons must have a solid understanding of the disease in order to better its identification.

Author (S) Details

Sapna Goel
Department of Pathology, SHKM Government Medical college, Nalhar, Nuh, Mewat, Haryana, India.

Kanwar Singh Goel
Department of General Surgery, Faculty of Medicine & Health Sciences, (SGT Medical College) Under SGT University, Budhera, Gurugram, Haryana, India.

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