Antimicrobials are the synthetic molecules obtained from natural sources are widely used against pathogenic microbes. The improper use of these antimicrobial agents has resulted in multi-drug resistance property among various pathogens and is a great threat to the global population. Also, the spread of these resistant microbes is a great challenge to the medical practitioners. The use of novel technologies to replace conventional antimicrobials can curtain antimicrobial resistance. Nanotechnology driven innovations could give a hope for the patients as well as physicians in solving the problem of drug resistance. The medical and veterinary application of nanomaterials which are in the size of atomic or molecular scale has been tremendously increased. It has been well known that metallic compounds have high antimicrobial/bactericidal activity. Various nanomaterials have been documented against several bacteria. The development of an effective nanocomposite requires a profound knowledge on both physicochemical features of nanomaterials and biological characteristics of microbes. In addition, the health hazards linked to various nanoparticles need to be addressed thoroughly.